New
Service for TodaysSeniorsNetwork.com
readers...roll mouse over, click on
highlighted links in stories to review items
from Amazon
Now, keep up to date
with daily feeds of newly posted stories
about America's Seniors...click on the box
to the left
Dietary Risk Factors associated with
incidence of Prostate Cancer
Newswise — June Chan from UCSF presented on
Nutritional Epidemiology of Prostate Cancer.
In a population migration study, low-risk
CaP populations moving to a high-risk area
shifted to a higher risk profile.
Chinese men in China had a CaP risk of
3/100,000, but after moving to the US this
increased to 100-120/100,000 by three
generations later. This supports the notion
that epigenetic events contribute to CaP
risk.
Dietary risk factors that increase risk of
CaP include foods high in calcium (and
possibly processed foods and red meats) and
foods that decrease risk include foods rich
in lycopene and selenium (and possibly
legumes, vegetables, Vit E, antioxidants,
fish and marine n-3 fatty acids).
However, from an epidemiologic standpoint
there are interpretation caveats that can
influence the presumed risk factors, Chan
stated.
CaP heterogeneity will influence outcomes
and one must consider that incidence vs.
progression vs. mortality are carefully
defined in studies. Among incident cases,
one must separate between aggressive vs.
non-aggressive disease.
The influence of PSA screening and other
interactions must also be taken into
account. For example, CaP heterogeneity
impacts the incidence percentage of
high-risk vs. low-risk CaP among those
taking either lycopene based foods or
calcium.
Another example is the interaction of
antioxidant intake and the MnSOD genotype,
showing the influence of genotype on
nutrition that can confound some studies.
In the CaPSURE database, diet and CaP
progression were analyzed by multivariate
analysis. Most patients included in her
analysis had low or intermediate risk CaP
(70% and 25%, respectively). A protective
effect of vegetables was noted, but not for
fish.
...
...
...