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Broccoli
Sprouts may prevent Stomach Cancer by
defeating Helicobacter Pylori
Newswise — Three-day-old broccoli sprouts, a
widely available human food, suppressed
Helicobacter pylori (H. pylori) infections,
according to a report in Cancer Prevention
Research, a journal of the American
Association for Cancer Research.
H. pylori infections are one of the most
common bacterial infections worldwide and
are a major cause of stomach cancer.
The cancer protective effects of
sulforaphane, a phytochemical from broccoli,
have been known for almost two decades, but
this is the first study to show an effect of
broccoli in humans on the bacterial
infection that leads to stomach cancer.
In this study, researchers enrolled 48
Helicobacter-infected Japanese men and women
and randomly assigned them to eat 70 grams
of fresh broccoli sprouts daily for eight
weeks or an equivalent amount of alfalfa
sprouts.
“Broccoli has recently entered the public
awareness as a preventive dietary agent.
This study supports the emerging evidence
that broccoli sprouts may be able to prevent
cancer in humans, not just in lab animals,”
said Jed Fahey, Sc.D., a faculty research
associate in the Department of Pharmacology
at Johns Hopkins School of Medicine.
Researchers assessed the severity of H.
pylori infection at enrollment, and again at
four and eight weeks using standard breath,
serum and stool tests.
H. pylori levels were significantly lower at
eight weeks on all three measures among
those patients who had eaten broccoli
sprouts, while they remained the same for
patients who had eaten alfalfa sprouts.
A reduction in H. pylori is expected to lead
to a reduction in stomach cancer due to
their well-established cause-and-effect
link.
Stomach cancer has a grim prognosis and is
the second most common and the second
deadliest cancer worldwide.
The mission of the American Association for
Cancer Research is to prevent and cure
cancer. Founded in 1907, AACR is the world’s
oldest and largest professional organization
dedicated to advancing cancer research.
The membership includes more than 28,000
basic, translational and clinical
researchers; health care professionals; and
cancer survivors and advocates in the United
States and 80 other countries.
The AACR marshals the full spectrum of
expertise from the cancer community to
accelerate progress in the prevention,
diagnosis and treatment of cancer through
high-quality scientific and educational
programs.
It funds innovative, meritorious research
grants. The AACR Annual Meeting attracts
more than 17,000 participants who share the
latest discoveries and developments in the
field.
Special conferences throughout the year
present novel data across a wide variety of
topics in cancer research, treatment and
patient care.
The AACR publishes five major peer-reviewed
journals: Cancer Research; Clinical Cancer
Research; Molecular Cancer Therapeutics;
Molecular Cancer Research; and Cancer
Epidemiology, Biomarkers & Prevention.
The AACR’s most recent publication and its
sixth major journal, Cancer Prevention
Research, is dedicated exclusively to cancer
prevention, from preclinical research to
clinical trials.
The AACR also publishes CR, a magazine for
cancer survivors and their families, patient
advocates, physicians and scientists.
CR provides a forum for sharing essential,
evidence-based information and perspectives
on progress in cancer research, survivorship
and advocacy.
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