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Old dogs offer new tricks
for keeping the mind sharp

February 6, 2005 (Fisher Center for Alzheimer's Research Foundation) -- Aging beagles supplied with a diet rich in nutrients found in fruits and vegetables, given exercise, and social and environmental stimulation remained more youthful and smarter than canines given run-of-the-mill treatment, a new study from the National Institute of Aging (NIA) reports. The report, published in the scientific journal Neurobiology of Aging, offers new insights into a range of factors that may keep the brain in peak condition into old age in humans as well.

While "obviously not people," notes study leader Dr. William Milgram, professor of psychology at the University of Toronto in Canada, "dogs have similar brain structures, develop similar brain pathologies, have similar nutritive requirements, and live in similar environments." Diet, exercise, social interaction, and mental stimulation are often cited in studies of people as ways to keep the mind sharp and perhaps even help to ward off the ravages of Alzheimer's disease. This study looked at these various potential brain-boosting components in various combinations.

In the study, researchers divided 48 older beagles, ages 7 to 11, into four groups. One group received regular dog food and standard care. The second group got a nutrient-rich special diet fortified with vitamins E and C from tomatoes, carrots, spinach, and citrus fruits, providing the equivalent of five or six servings of fruits and vegetables a day. The third group got standard dog food but an environment enriched by daily contact and play with other dogs, regular exercise, and special toys and games. The fourth group got both the enriched diet and environmental stimulation.

Over the next two years, the dogs were regularly tested with increasingly difficult mental acuity tasks, such as learning how to uncover treats under black or white- blocks. Those dogs who got the enriched diets, exercise, and social stimulation performed much better on these tests than those given standard care. Having any one of the enrichments, such as a nutrient-dense diet, exercise, or environmental stimulation, also improved results, but not as much as having all three.

 
"This research brings a note of optimism that there are things that we can do that may significantly improve our cognitive
health," says Dr. Molly Wagster, Ph.D., program director of the NIA's Neuropsychology of Aging Branch. "In this case, more was better. Although each factor alone was capable of improving cognitive function in older animals, the combination was additive, pointing to a healthy lifestyle as the most beneficial approach. While we have yet to demonstrate these benefits in people, research such as this gives us new ways to think about the aging brain and what we can do to keep it intact."

The study highlights a growing body of evidence that proper diet, plenty of exercise, and mental stimulation may help to keep the mind sharp as we age. While no one food or treatment can ward off Alzheimer's, doctors are hopeful that lifestyle measures such as these can help to keep the aging brain more youthful and alert. The Fisher Center for Alzheimer Research Foundation's and its Alzheimer's Information Site, alzinfo.org, continue to lead the way in a search for a cure . 

 

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